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John J. Kepes, MD
Kansas City, Kan

Arch Neurol. 1975;32(6):421.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—In the February 1975 issue of the Archives (32:75), Dr. Derakhshan wrote a challenging article on the value of Negri bodies in the diagnosis of rabies. Whereas one can easily agree with his advocacy of electron microscopic and immunofluorescent methods in "nailing down" the diagnosis of rabies in human or animal material, I have some misgivings about his choice of the case he uses to support his argument.

The Purkinje cell inclusions in Dr. Derakhshan's case are, to me at least, reminiscent of the inclusion bodies first described by Sabina Strich in 1966, in two out of three children who suffered from ataxia telangiectasia.¹ I have encountered such inclusions in the brain of an adolescent with the Marfan syndrome and mental retardation but no ataxia telangiectasia. These were predominantly eosinophilic but some of them had an occasional basophilic granule on hematoxylin-eosin stain. Dr. Strich, who reviewed . . . [Full Text PDF of this Article]

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