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Convulsions in Hamsters After Cream MealsElectroencephalograms and Available Cerebral Oxygen
ROY L. SWANK, M.D.;
HARUOMI NAKAMURA, M.D., Ph.D.
Arch Neurol. 1960;3(5):594-600.
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In an earlier paper Swank and Engel1 showed that most hamsters fed large cream fat meals developed convulsions. The seizures first appeared about 3 hours after feeding. They were first focal. Later they became generalized. Many of the animals which developed generalized seizures did not survive. After feedings of equally large meals of vegetable oil, only an occasional focal, or no seizures were seen.
The purpose of this paper is to explore more completely the relationship of different triglycerides to the occurrence of the seizures and to report the changes in the electroencephalograms and in available cerebral oxygen which accompany the seizures.
Materials and Methods
Golden hamsters weighing 60 to 100 gm. were used as the experimental animal. Naturally occurring fats and oils and mixtures of synthetic and naturally occurring triglycerides were fed by stomach tube while the animals were under very light ether anesthesia.* Electroencephalograms were made by
. . . [Full Text PDF of this Article]
Author Affiliations
Portland, Ore.
From the Division of Neurology, Department of Medicine, University of Oregon Medical School, Portland, Ore.
Footnotes
Received for publication June 10, 1960.
Supported by Public Health Grant H-2676 and Life Insurance Grant G6-55-44.
We wish to thank Mr. Lavelle Jackson for his assistance in this part of the study.
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