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LUIZ C. MATTOSINHO FRANCA, M.D.; ALVAN G. FORAKER, M.D.

Arch Neurol. 1960;3(4):416-419.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Recent developments in light microscopy have permitted a new approach to the morphology of the nervous system by use of unstained tissue sections. Von Hirsch and Hager^1,2 investigated aspects of the normal and pathological histology of the central nervous system with the use of phase-contrast microscopy. The same method was used by Calvo³ to study smears of brain tumors. Phase-contrast microscopy was demonstrated to be a useful tool for morphological, qualitative studies of histology.⁴ The later development of interference microscopy brought forth the possibility of adding quantitative determinations to the qualitative examination. Interferometric determination of cell thickness, dry cellular mass, and the results of the extraction of various substances from nuclei have been reported.^5-9 Thorough discussions of the principles of interference microscopy, types of microscopes, and sources of error were made by Barer¹⁰ and by Hale.¹¹ In our laboratory we have applied microscopic interferometry . . . [Full Text PDF of this Article]

Author Affiliations
Jacksonville, Fla.

From the Research Laboratory, Baptist Memorial Hospital.

Footnotes
Received for publication June 21, 1960.

Mrs. Elizabeth Anderson assisted technically.

Read at the meeting of the Histochemical Society, New York, April 10, 1960.

The tissue blocks used in this study were furnished by Dr. Lowell W. Lapham, Institute of Pathology, Western Reserve University, Cleveland.

This investigation was supported by research grants from the Florida Heart Association, Inc., the Damon Runyon Memorial Fund (DRG-352 C), and the National Cancer Institute (C-2719 and H-4321), National Institutes of Health, Public Health Service.

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