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Its Relation to Parkinsonism

JACK STERN, M.D.; ARTHUR WARD, Jr., M.D.

Arch Neurol. 1960;3(2):193-204.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

With the recent increasing success of stereotactic surgery of the thalamus in the treatment of Parkinsonism, renewed interest in the function of the ventrolateral nucleus of the thalamus has been awakened, Particularly with respect to its role in the Parkinsonian state. Previous hypotheses by one of us (A. A. W.)²⁵ regarding the pathophysiology underlying the symptoms of Parkinsonism have not included any definition of the role played by either ventrolateral thalamic or pallidal circuit. In addition to postulated dysfunction of extrapyramidal circuits, altered peripheral and cord mechanisms have also been invoked in the attempt to explain rigidity, akinesia, and tremor. Byrnes³ stated that lesions are present in the muscle spindle itself which are specific for postencephalitic Parkinson's disease. He described degeneration of the intrafusal nerve and eventual disintegration of the muscle spindle. However, there has been no confirmation of these observations. Hassler¹⁰ has postulated that paralysis . . . [Full Text PDF of this Article]

Author Affiliations
Seattle

Footnotes
Accepted for publication March 30, 1960.

Division of Neurosurgery, University of Washington School of Medicine.

This investigation was supported in part by a research grant from Parkinson's Disease Foundation, Inc.

Post-Doctoral Fellow (Dr. Stern), National Institutes of Health, U.S. Public Health Service (BF 9130).

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