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Neonatal Jaundice and Mental Retardation
WOLF W. ZUELZER, M.D.
Arch Neurol. 1960;3(2):127-135.
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Until quite recently, mental retardation in combination with a variety of neurologic abnormalities was a frequent finding in children who had survived hemolytic disease of the newborn. It has been known for some time that kernicterus, an acute acquired encephalopathy of the newborn period is the basis for these residues.
The term kernicterus was derived from the presence of bright yellow pigmentation in certain nuclear masses of the brain found at autopsy in infants dying in the acute phase and had at first purely pathologicanatomic connotations. Later it began to assume clinical meaning and now has come to refer to a variable but nonetheless characteristic acute neurologic syndrome observed in severely jaundiced newborn infants. Through clinical and pathologic studies1-3 it has become clear that kernicterus is not a specific complication of hemolytic disease of the newborn but may occur in a variety of situations affecting this age group which
. . . [Full Text PDF of this Article]
Author Affiliations
Detroit
From The Child Research Center of Michigan, Children's Hospital of Michigan, and the Department of Pediatrics, Wayne State University College of Medicine.
Footnotes
Received for publication April 8, 1960.
This work was supported by grants from the National Institutes of Health (RG-5105), the Children's Leukemia Foundation of Michigan, and the Cerebral Palsy Fund, Lambda Tau Delta.
Reprinted by permission from Bowman, Peter W., and Mautner, Hans V. (Editors): Mental Retardation: Proceedings of the First International Medical Conference on Mental Retardation, New York, Grune & Stratton, Inc., 1960.
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