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Spastic Pseudosclerosis—Encephalomyelopathy with Disseminated Foci of Degeneration

A. Jakob

Arch Neurol. 1971;25(6):573.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

.... We are dealing with an illness of middle and advanced age... that begins with slowly progressive motor and sensory symptoms. The patients complain of weakness and pain in the extremities, especially the legs, which become stiff. The legs often give way during walking, causing the patient to fall. Objective findings are usually minimal, but spasticity and an early diminution in the abdominal reflexes may be present. It should be emphasized that the motor disturbances have a functional quality early in the disease, and the symptoms fluctuate in severity. Gradually, however, more distinct disturbances of movement appear, which often exhibit a peculiar mixture of spastic and striatal signs that are difficult to analyze. Without showing demonstrable weakness, the patient's locomotion is strikingly incoordinated..., and finally standing and walking become impossible....

Speech is slow and monotonous, and is often... dysarthric. Tendon reflexes are usually increased, but may be normal or even absent. . . . [Full Text PDF of this Article]

Author Affiliations
From the Anatomical Laboratory of the University Psychiatric Clinic and State Hospital of Hamburg—Friedrichsberg [Prof. Dr. Weygandt]); [Creutzfeldt's case is reviewed, but Jakob's three cases are presented in detail]

Footnotes
Translation of: Über eigenartige Erkrankungen des Zentralnervensystems mit bemerkenswertem anatomischen Befunde (Spastische Pseudosklerose—Encephalomyelopathie mit disseminierten Degenerationsherden.) Zeitschrift für die gesamte Neurologie und Psychiatrie 64:147-228, 1921.

Presented as an abstract at the meeting of German neurologists in Leipzig, 1920 (Congress Report).

Supplement:... I have been able to investigate one further case, which corroborates the foregoing statements. It will be reported in Med. Klin., 1921.

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