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Robert H. Wilkins, MD; Irwin A. Brody, MD

Arch Neurol. 1971;25(6):572.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN 1920, Hans Gerhard Creutzfeldt of Berlin (1885 to 1964) published a detailed case report of a patient with an unusual combination of neurological signs and pathological findings.^1,2 Then within three years, the neuropathologist Alfons Jakob of Hamburg (1884 to 1931), a student of Nissl and Alzheimer,³ described five similar cases and established this condition as a distinct disease entity.^4-7 Despite Creutzfeldt's priority, the disorder is often called Jakob-Creutzfeldt disease because of Jakob's greater contribution to its delineation.⁸

It is now recognized that this disease or group of diseases is manifested by a rapidly progressive dementia combined with pyramidal and extrapyramidal signs, myoclonus, and often with amyotrophy.^9-10 The disease affects middle aged individuals of both sexes and is usually fatal in a few months to a few years. Neuronal degeneration and gliosis occur in the brain and spinal cord, and glial rosettes may be found . . . [Full Text PDF of this Article]

Author Affiliations
Durham, NC

From the Divisions of Neurosurgery and Neurology, Duke University Medical Center and the Durham Veterans Administration Hospital, Durham, NC.

Footnotes
Accepted for publication July 2, 1971.

Reprint requests to Duke University Medical Center, Durham, NC 27710 (Dr. Wilkins).

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