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Effects on Penicillin-Induced Focal Seizures in the Cat

Leroy Sharer, MD; Henn Kutt, MD

Arch Neurol. 1971;24(2):169-175.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE BENZODIAZEPINE compound, diazepam, was noted to have anticonvulsant properties when used to prevent strychnine, pentylenetetrazol, and electroshock convulsions (Randall et al, 1961,¹ and Swinyard and Castellion, 1966²). Lanoir et al³ reported a diminution of the after-discharges resulting from stimulation of the amygdala and cortex as well as an elevation of the threshold to pentylenetetrazol seizures in cats pretreated with diazepam. Schallek et al,⁴ using lower doses, reported raising the threshold to after-discharges of the thalamus but not of the cortex or amygdala. Hernandez-Peon et al⁵ concluded from their experiments on electrical stimulation of the amygdala, hippocampus, and precruciate motor cortex in the cat that diazepam "has a generalized depressant action upon epileptogenic structures throughout the brain." Naquet and his colleagues⁶ reported on the successful termination of status epilepticus in cats with cicatricial lesions, and Spehlmann and Colley⁷ were able to . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Department of Neurology, Cornell University Medical College, New York.

Footnotes
Accepted for publication Sept 22, 1970.

Reprint requests to Department of Neurology, New York Hospital-Cornell Medical Center, 525 E 68th St, New York 10021 (Dr. Kutt).

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