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Recurrent Polyneuropathy and Neurolymphomatosis
Adam Borit, MD;
Paul H. Altrocchi, MD
Arch Neurol. 1971;24(1):40-49.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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RECURRENT polyneuropathy is a rare disorder, especially cases with more than one relapse. Reports of necropsied cases are extremely rare.
It is the purpose of this paper to describe the clinical and pathological features of a patient with recurrent polyneuropathy who had many relapses over a period of 31 years. The unusual clinical picture was associated with striking findings at necropsy: there was widespread, but focal, infiltration by lymphoid cells of the peripheral nerves and their ganglia as well as of the leptomeninges and the larger Virchow-Robin spaces of the entire central nervous system (CNS), suggesting a lymphoproliferative process. This combination of clinical and pathological findings has not been previously described in man, but there is considerable resemblance to the disorder known in veterinary medicine as Marek's disease or neurolymphomatosis gallinarum, a polyneuropathy of chickens which recent studies have shown to be of probable viral etiology.
Report of a
. . . [Full Text PDF of this Article]
Author Affiliations
Palo Alto, Calif
From the departments of pathology (neuropathology) (Dr. Borit), and medicine (neurology) (Dr. Altrocchi), Stanford University School of Medicine and the Palo Alto Medical Clinic, Palo Alto, Calif.
Footnotes
Accepted for publication Sept 18, 1970.
Reprint requests to Department of Neuropathology, Harvard Medical School, 25 Shattuck St, Boston 02115 (Dr. Borit).
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