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Willem A. den Hartog Jager, MD

Arch Neurol. 1970;23(6):528-533.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN 1912, Lewy¹ described cytoplasmic hyaline inclusions in the substantia innominata and the dorsal vagal nucleus in paralysis agitans. Trétiakoff² described these inclusion bodies in the substantia nigra. In a previous paper³ I discussed the significance attached by various authors to these Lewy bodies, demonstrating additionally by a lipid-histochemical study that these Lewy bodies contain sphingomyelin.

The next question concerned the relationship between the partial disintegration of such structures as the substantia nigra (in Parkinson's disease) and the disturbed catecholamine metabolism in the basal nuclei on the one hand⁴ and sphingomyelin storage on the other hand. There is one organ in the body which is a veritable catecholamine plant: the medulla of the adrenal gland. This is why an investigation was made into a possible disturbance of lipid metabolism in the adrenal glands in two patients with Parkinson's disease. As a control the adrenal . . . [Full Text PDF of this Article]

Author Affiliations
Amsterdam

From the Department of Neurology, Laboratory of Experimental Neurology, Wilhelmina Gasthuis, University of Amsterdam, Amsterdam.

Footnotes
Accepted for publication July 9, 1970.

Reprint requests to Wilhelmina Gasthuis, Amsterdam (Dr. den Hartog Jager).

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