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Blood Levels in Bedfast Patients

Raymond G. Auger, MD; John E. Zehr, PhD; Robert G. Siekert, MD; William E. Segar, MD

Arch Neurol. 1970;23(6):513-517.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

HYPONATREMIA occurs commonly in patients with severe intracranial disease or head injury who are maintained on a normal intake of water. Such patients typically have hyperosmotic urine and urine-to-serum osmolal ratios greater than one. These findings could result from dehydration and sodium loss. However, when they occur in hydrated patients, particularly those who have received an adequate intake of sodium, it is assumed that the blood level of antidiuretic hormone (ADH) is elevated; a dilute urine, therefore, cannot be elaborated and, if the water intake is maintained at the usual level, hyponatremia occurs. This series of events was termed the "syndrome of inappropriate antidiuretic hormone secretion" (SIADH) by Schwartz et al¹ in 1957. Since that time, an impressive body of direct and indirect evidence has shown that the blood ADH level is elevated in these circumstances. It is generally believed that the lesion producing the intracranial disease . . . [Full Text PDF of this Article]

Author Affiliations
Rochester, Minn

From the Mayo Graduate School of Medicine (University of Minnesota) (Drs. Auger and Zehr), and the departments of neurology (Dr. Siekert) and pediatrics (Dr. Segar), Mayo Clinic and Mayo Foundation, Rochester, Minn.

Footnotes
Accepted for publication Sept 8, 1970.

Reprint requests to Section of Publications, Mayo Clinic, 200 First St SW, Rochester, Minn 55901.

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