This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

David A. Drachman, MD; Philip Y. Paterson, MD; Byron S. Berlin, MD; Jadwiga Roguska, MD

Arch Neurol. 1970;23(5):385-393.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ALTHOUGH idiopathic polyneuritis, or the "Landry-Guillain-Barré (LGB) syndrome" has been known for more than 100 years,¹ its nosologic limits, etiology, and treatment remain a matter of controversy.^2-23 Current opinion favors an autoallergic pathogenesis, and many authors have drawn attention to experimental allergic neuritis (EAN) first described by Waksman and Adams²⁴ as the appropriate experimental model of this clinical condition.^12,14-17 As a natural outgrowth of this concept, immunosuppressive treatment has been suggested as specific therapy for the LGB syndrome. Experimentally, steroids have been shown to prevent EAN,²⁵ and both steroids and immunosuppressive drugs will prevent the closely related experimental allergic encephalomyelitis (EAE) consistently in animals.^26-30 With but one exception,³¹ the drugs are effective only if given before the onset of clinical evidence of paralysis. The use of steroids and adrenocorticotropic hormone in humans with idiopathic polyneuritis has been less successful, however.^5,7,10,12,-^17,21-23,32 . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

From the Department of Neurology (Dr. Drachman); the Section of Infectious Diseases—Hypersensitivity, Department of Medicine (Dr. Paterson); Northwestern University Clinical Virology Laboratory, departments of medicine and pathology (Dr. Berlin); and the Renal Section, Department of Medicine (Dr. Roguska); Northwestern University McGaw Medical Center, Chicago.

Footnotes
Accepted for publication June 13, 1970.

Read in part before the 22nd annual meeting of the American Academy of Neurology, Bal Harbour, Fla, May 2, 1970.

Reprint requests to Northwestern University Medical School, 303 E Chicago Ave, Chicago 60611 (Dr. Drachman).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?