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Action of Increased K+ in Extracellular Spaces of the Brain

Emil C. Zuckermann, MD; Gilbert H. Glaser, MD

Arch Neurol. 1970;23(4):358-364.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

INVESTIGATIONS carried out in our laboratory during the past three years have demonstrated that relatively small increases in potassium (K⁺) concentration in the cerebrospinal fluid (CSF) perfused over the dorsal hippocampus¹ or neocortex² can initiate seizure activity in these structures. A latent period of 15 to 40 minutes elapses between the beginning of the perfusion and the start of seizure activity, indicating the presence in the normal brain of probably functional barriers protecting neurons against K⁺ accumulation. Analysis of evoked responses³ and slow potential (DC) shifts⁴ during the period in which the epileptogenic phenomena are built up disclosed almost identical changes with those induced by rapid repetitive electrical epileptogenic stimulation of the same structures. These findings, along with data obtained by others,^5-11 have led to the hypothesis that a localized increase of potassium in the extracellular spaces of the brain could be able to . . . [Full Text PDF of this Article]

Author Affiliations
New Haven, Conn

From the Section of Neurology, Yale University School of Medicine, New Haven, Conn.

Footnotes
Accepted for publication June 9, 1970.

Read in part before the Ninth International Congress of Neurology, New York, Sept 25, 1969.

Reprint requests to Section of Neurology, Yale University School of Medicine, 333 Cedar St, New Haven, Conn 06510 (Dr. Glaser).

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