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II. Microchemical and Histologic Study of Myelin Formation in the Rat
Norman H. Bass, MD;
Martin G. Netsky, MD;
Elizabeth Young
Arch Neurol. 1970;23(4):303-313.
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PREVIOUS biochemical and morphologic studies of the brain indicate that the amount of myelin is severely reduced when rats are malnourished during the first 21 days of postnatal life.1-6 This period of cerebral development was proposed as a vulnerable phase with respect to formation of myelin.7-10 Lipids such as cerebroside, sulfatide, cholesterol, proteolipids, and plasmalogens are concentrated in myelin11 and are greatly decreased in the brains of undernourished suckling rats.12,13 These chemical findings have been correlated with a decrease in the amount of myelin stained by the method of Loyez.5 The activity of galactocerbroside sulfokinase and the incorporation of sulfatide into myelin of the rat also was reduced by neonatal malnutrition.6 This reduction in amount of myelin persists throughout adult life despite prolonged nutritional rehabilitation.6-13 Histologic and biochemical recovery of the myelin content of the brain under these experimental conditions has been
. . . [Full Text PDF of this Article]
Author Affiliations
Charlottesville, Va
From the departments of neurology (Dr. Bass and Miss Young) and pathology (Dr. Netsky), University of Virginia School of Medicine, Charlottesville, Va 22901. Dr. Bass is a John and Mary R. Markle scholar in academic medicine.
Footnotes
Accepted for publication May 14, 1970.
Reprint requests to Department of Neurology, University of Virginia School of Medicine, Charlottesville, Va 22901 (Dr. Bass).
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