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Cerebral Water and ElectrolytesEffect of Asphyxia, Hypoxia, and Hypercapnia
John W. Norris, MD;
Hanna M. Pappius, PhD
Arch Neurol. 1970;23(3):248-258.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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DESPITE an ever-growing literature on the subject, the basic pathological mechanisms concerned in the effect of oxygen lack on the brain remain largely unknown.1 One reason for confusion in this field has been the synonymous use of the terms anoxia and ischemia. For example, it is still widely held that "anoxia" will under certain conditions produce cerebral edema,2-5 this term implying, in some instances, deprivation of the organism's oxygen supply and, in others, diffuse cerebral ischemia which involves many other factors in addition to anoxia. The importance of this "anoxic edema" concept has immediate and obvious implication for the clinician, since it is recognized that an increase in brain volume may in itself prove fatal by compression of vital structures.6
Much of the evidence supporting the anoxic edema hypothesis was based either on histopathological findings now believed to belargely artifactual7 or indirectly on measurements of
. . . [Full Text PDF of this Article]
Author Affiliations
Montreal
From the Donner Laboratory of Experimental Neurochemistry, the Department of Neurology and Neurosurgery, McGill University, and the Montreal Neurological Institute, Montreal. Dr. Norris was a fellow of the Medical Research Council of Canada. Dr. Norris is now with the Department of Neurology, Sunnybrook Hospital, Toronto.
Footnotes
Accepted for publication March 13, 1970.
Reprint requests to Donner Laboratory of Experimental Neurochemistry, Montreal Neurological Institute, 3801 University St, Montreal 112 (Dr. Pappius).
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