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Julian T. Hoff, MD; Donald J. Reis, MD

Arch Neurol. 1970;23(3):228-240.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THAT an acute elevation of intracranial pressure results in a rise of the systemic blood pressure and a fall of heart rate has been known for many years.^1-3 In 1902, Cushing^4,5 first demonstrated the quantitative nature of this response, showing that it was graded and occurred when the pressure within the head exceeded that of the systolic blood pressure. Furthermore, the response he observed was reversibly abolished by instilling cocaine into the cisterna magna. Cushing speculated that ischemia of the brain stem was the stimulus for the response and that it was in some manner mediated by the caudal brain stem. Since his report, the vasomotor phenomenon he described has become known as the Cushing "reflex." Because the reflex nature of the response has never been clearly established, however, in this paper it will be referred to as the Cushing response.

It was never proved by Cushing, nor . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the department of surgery (neurosurgery) (Dr. Hoff) and neurology (Dr. Reis), Cornell University Medical College, New York.

Footnotes
Accepted for publication Jan 20, 1970.

Reprint requests to Department of Neurology, Cornell University Medical College, 1300 York Ave, New York 10021 (Dr. Reis).

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