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Psychosis and Other Psychiatric Manifestations of Levodopa Therapy
Gastone G. Celesia, MD;
Arlene N. Barr, MD
Arch Neurol. 1970;23(3):193-200.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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IN RECENT years levodopa has proved to be the most effective agent presently available for the treatment of parkinsonism.1-6 Among the side effects of levodopa therapy, psychiatric disturbances have been noted.3-6
Levodopa is not only the precursor of dopamine hydrochloride but also of norepinephrine.7 Although the action of these two catecholamines upon the central nervous system is incompletely understood, evidence has been accumulated in the last two decades upon their action in behavior.8,9 In this context we would like to report 16 cases of psychiatric disturbances which occurred among 45 patients treated with levodopa.
Method
Levodopa was administered to 45 patients (31 men and 14 women) with Parkinson's syndrome. Forty-one patients had primary parkinsonism or Parkinson's disease, three had postencephalitic parkinsonism, and one had arteriosclerotic parkinsonism. Of the patients willing to enter the program, only those with decompensated cardiovascular disease, renal disease, psychosis
. . . [Full Text PDF of this Article]
Author Affiliations
Madison, Wis
From the Department of Neurology, University of Wisconsin Medical Center, and Veterans Administration Hospital, Madison, Wis.
Footnotes
Accepted for publication April 21, 1970.
Reprint requests to Department of Neurology, University of Wisconsin Medical School, Madison, Wis 53706 (Dr. Celesia).
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