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An Experimental Model With Evaluation of Dexamethasone

Victor M. Benson; Robert L. McLaurin, MD; Ernest C. Foulkes, PhD

Arch Neurol. 1970;23(2):179-186.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THERE is no well established treatment for cerebral edema of traumatic origin. Experimental work has been hampered by lack of methods for the uniform induction and measurement of this type of edema. The present study was devoted to development of such a model in the rat and an evaluation of the therapeutic effects of dexamethasone.

To test the efficacy of various agents in reducing intracranial damage secondary to head injury, an experimental method should meet several criteria: (1) the amount of damage produced should be controllable and uniform; (2) the method of measurement should be sensitive enough to detect small differences in the extent of the damage; (3) the whole brain should be examined since, as in human posttraumatic edema, experimentally induced edema may not involve the entire brain uniformly; and (4) to facilitate study of large numbers of animals, both induction and measurement of injury should be accomplished . . . [Full Text PDF of this Article]

Author Affiliations
Cincinnati

From the Division of Neurosurgery and the Laser Laboratory, Children's Hospital Research Foundation, University of Cincinnati, Cincinnati.

Footnotes
Accepted for publication March 28, 1970.

Reprint requests to Cincinnati General Hospital, 3231 Burnet Ave, Cincinnati 45229 (Dr. McLaurin).

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