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Hypothalamic Glioma in a Child

Ronald Brisman, MD; Abe M. Chutorian, MD

Arch Neurol. 1970;23(1):63-69.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE SYNDROME of inappropriate antidiuretic hormone (SIADH) secretion is characterized by serum hyponatremia and hyposmolality associated with relative urinary hyperosmolality and excessive renal salt loss; there is an absence of clinical evidence of fluid volume depletion, and renal and adrenal function are normal.¹ The subject of this report, a child with a hypothalamic glioma, fulfilled all of these criteria and, in addition, showed several atypical features of the SIADH. These included a normal response to an acute water load, the occasional failure to respond to severe water restriction, and the discontinuous secretion of a measurably elevated ADH co-existing with persistent hyponatremia. These features are not inconsistent with the inappropriate secretion of ADH. A possible alternative explanation is that a malfunctioning hypothalamic "osmostat" may be an associated defect.

Report of a Case

This 6-year-old boy was hospitalized on Oct 19, 1968, because of headaches and vomiting of several . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the departments of neurological surgery (Dr. Brisman) and pediatric neurology (Dr. Chutorian), Neurological Institute, College of Physicians and Surgeons, Columbia University, New York.

Footnotes
Submitted for publication Dec 1, 1969; accepted Dec 31.

Reprint requests to Neurological Institute, 710 W 168th St, New York 10032 (Dr. Chutorian).

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