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The Role of Pyridoxine

Dennis B. Smith, MD; Brian B. Gallagher, MD, PhD

Arch Neurol. 1970;23(1):59-62.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE PRESENCE of clinical seizures in Wilson's disease is unusual. When seizures do occur, they tend to appear late in the course of the disease, often shortly before death.^1-3 In more than half the cases of Wilson's disease in which Heller and Kooi⁴ were able to document electroencephalographic changes, the records were abnormal and the degree of generalized abnormality tended to parallel the overall severity of the clinical course.⁴ More recently, however, Hansotia et al³ showed that while mild nonspecific changes in the EEG bore no clear relationship to the degree of central nervous system involvement, marked abnormalities including seizure discharges were seen only with severe complications of the disease.

In 1966, Gibbs and Walshe⁵ reported a patient with Wilson's disease who developed Jacksonian epilepsy after 26 months of penicillamine therapy at a time when the neurological manifestations otherwise were showing a striking improvement. Smith . . . [Full Text PDF of this Article]

Author Affiliations
New Haven, Conn

From the Section of Neurology, Yale University School of Medicine, New Haven, Conn.

Footnotes
Submitted for publication Dec 13, 1969; accepted Dec 24.

Reprint requests to Department of Neurology, DeGosbriand Unit, University of Vermont College of Medicine, Burlington, Vt 05401 (Dr. Smith).

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