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Use of an Encephalitogen of Human Origin, With a Report of a Trial of Immunosuppressive Therapy in Multiple Sclerosis

Peter C. Dau, MD; Raymond D. A. Peterson, MD

Arch Neurol. 1970;23(1):32-40.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

PEARMIN et al¹ in 1963 were the first to demonstrate antigen stimulated mitosis of specifically sensitized leukocytes in tissue culture. These stimulated cells had the same blast-like morphologic appearance as the cells previously described by Hungerford et al² and Nowell³ as "transformed" in response to phytohemagglutinin (PHA), which initiates this response independently of previous immunologic sensitization. Since then, a specific transformation response has been demonstrated to many different antigens and has been found to correlate better with delayed hypersensitivity than with circulating antibody.⁴

The idea was quickly proposed that the transformation response could be used as a test for specific sensitization in diseases thought to be of autoimmune etiology.⁵ Several authors^6-14 have now reported transformation studies of leukocytes from patients with multiple sclerosis. The results of those studies in which morphological methods were used to evaluate the transformation response to neural antigens have . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

From the Division of Neurology, Department of Medicine, and the Variety Club Research Center, La Rabida-University of Chicago Institute, University of Chicago, Chicago.

Footnotes
Submitted for publication Jan 12, 1970; accepted Jan 24.

Reprint requests to David Grant USAF Medical Center, MAC, Travis Air Force Base, Fairfield, Calif 94535 (Dr. Dau).

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