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Factors Regulating Amino Acid Concentration IN Feline Cerebrospinal Fluid

Joel Elisabeth Murray, MD; Robert W. P. Cutler, MD

Arch Neurol. 1970;23(1):23-31.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

USING automated chromatographic techniques, it has been possible to determine with precision in several mammalian species that the concentrations of many amino acids are considerably less in cerebrospinal fluid (CSF) than in plasma.^1-3 There is accumulating evidence that the low CSF to plasma ratios for many solutes are maintained in part by uphill transport from CSF to blood.^4-6 Such low CSF to plasma ratios have been considered to play a role in the regulation of tissue concentrations of these substances through a sink action.⁷ The need for understanding of the mechanisms which regulate amino acid concentrations in various portions of the nervous system is emphasized by the fundamental role which certain amino acids are thought to play in synaptic transmission, as well as the common occurrence of mental retardation in conjunction with aminoacidopathies.

The CSF concentration of glycine is one twentieth of that in . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

From the Section of Neurology, Department of Medicine, University of Chicago, Chicago.

Footnotes
Submitted for publication Nov 14, 1969; accepted Nov 29.

Reprint requests to University of Chicago, 950 E 59th St, Chicago 60637 (Dr. Cutler).

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