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Local and Remote Effect of Carbon Dioxide

Kyuya Kogure, MD; Peritz Scheinberg, MD; Oscar M. Reinmuth, MD; Masatoshi Fujishima, MD; Raul Busto

Arch Neurol. 1970;22(6):528-540.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE RESPONSE of cerebral circulation to changes in arterial carbon dioxide pressure (Pco₂) is well known, but the mechanisms whereby carbon dioxide (CO₂) alters the tone of cerebral vessels are still uncertain. It has been generally accepted that CO₂ acts directly upon vascular smooth muscle, although some of the evidence for this is tenuous.¹ Recent studies by Severinghaus and Lassen,² as well as Betz and Heuser³ imply that CO₂ acts by altering the pH of vascular smooth muscle, and that an ion-impermeable barrier between intima and muscularis inhibits a similar effect by decreased arterial pH alone. Studies by Shalit et al^1,4,5 oppose the concept of a direct effect of CO₂ on vessel walls and suggest that one of the mechanisms of action of CO₂ on cortical vessels might be indirect through the brain stem. Certainly the hypothesis that the . . . [Full Text PDF of this Article]

Author Affiliations
Miami. Fla

From the Department of Neurology, University of Miami School of Medicine, Miami, Fla. Dr. Kogure is now with the Second Department of Internal Medicine, Jikei University School of Medicine, Tokyo.

Footnotes
Submitted for publication Oct 28, 1969; accepted Nov 29.

Reprint requests to Department of Neurology, University of Miami School of Medicine, PO Box 875, Biscayne Annex, Miami, Fla 33152 (Dr. Scheinberg).

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