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Rainer Spehlmann, MD

Arch Neurol. 1970;22(6):510-514.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN THE PRECEDING paper¹ we reported that the visual cortex of the cat, partially deafferented by interruption of the optic radiation, developed increased sensitivity to electrical stimulation without showing acetylcholine (ACh) supersensitivity. This result was obtained by means of macroelectrodes which recorded the effect of electrical stimuli and of ACh solutions applied to the cortical surface. This method was chosen in order to permit comparison with earlier studies which showed that the chronically isolated cortex develops supersensitivity to topically applied ACh² and to electrical stimulation.³ Since macroelectrode recordings are not likely to reflect changes in individual deafferented neurons, we used multibarreled microelectrodes to study the firing of single neurons and the neuronal reaction to local electrophoretic ACh application. Some of the results have been communicated in a preliminary form.⁴

Materials and Methods

A series of cats was prepared as encéphale isolé ten days to one . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

From the Veterans Administration Research Hospital and the Department of Neurology, Northwestern University Medical School, Chicago.

Footnotes
Submitted for publication Oct 27, 1969; accepted Nov 29.

Read in part before the Ninth International Congress of Neurology, New York, Sept 26, 1969.

Reprint requests to Veterans Administration Research Hospital, 333 E Huron St, Chicago 60611 (Dr. Spehlmann).

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