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Relationship of Circulating Immunocytes to Disease Activity

Stuart D. Cook, MD; Peter C. Dowling, MD; John N. Whitaker, MD

Arch Neurol. 1970;22(5):470-474.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE Guillain-Barré syndrome (GBS) is an acute polyneuropathy of humans characterized histologically by mononuclear cell infiltrates and segmental demyelination.^1-3 Although described initially by Landry⁴ in 1859, and Guillain et al⁵ in 1916, the etiology and pathogenesis of this important disorder still remain unknown. In 1955, Waksman and Adams⁶ described a peripheral neuropathy in animals, experimental allergic neuritis (EAN), produced by the injection of peripheral nervous tissue in complete Freund's adjuvant. Because of the similar clinical and pathologic features in this immune-mediated experimental disease, and the GBS, a common mechanism of tissue injury was postulated.

Recent studies have shown that increased numbers of atypical basophilic mononuclear cells, many of which are synthesizing DNA, occur in peripheral blood during immune reactions.^7-9 These circulating sensitized cells, or immunocytes, are presumed to mirror the intense concomitant proliferation occurring in the host's lymphoid tissues. Circulating immunocytes have also . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Unit for Research in Aging and Saul Korey Department of Neurology, Albert Einstein College of Medicine, and Department of Neurology, College of Physicians and Surgeons, Columbia University, New York. Drs. Cook and Dowling are now with the Neurological Institute, Columbia-Presbyterian Medical Center, New York.

Footnotes
Submitted for publication Nov 6, 1969; accepted Dec 18.

Read in part before the Sixth National Meeting of the Reticuloendothelial Society, San Francisco, Dec 4, 1969.

Reprint requests to Neurological Institute, 710 W 168th St, New York 10032 (Dr. Cook).

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