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Relationship to Blood Gases in Goats

Joseph C. Cauthen, MD; Stanley R. Nelson, MD; Robert F. Hustead, MD; C. Richard Saylor, MD; John W. Overman

Arch Neurol. 1970;22(5):463-469.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

WHEN blood gas tensions vary from normal, brain metabolism is also affected. Generally, these alterations are not severe enough to have adverse clinical effects, but in the brain-damaged patient requiring ventilatory assistance, optimum brain metabolism may be necessary for a favorable outcome. Gotoh et al¹ found a reduction in cerebral blood flow during hypocarbia in man and considered the resulting cerebral hypoxia responsible for electroencephalogram slowing in the patients studied. Cain² also observed reduced blood flow in dogs during periods of hypocarbia (10 and 20 mm Hg), but oxygenation of the brain appeared adequate based on pyruvate and lactate differences in arterial and jugular venous blood. Alexander et al³ found increased conversion of brain glucose to lactate during hypocarbia in man. Elevation of pH has been shown to increase glycolysis in cat brain slices with associated increases in pyruvate and lactate production.⁴ Results obtained by . . . [Full Text PDF of this Article]

Author Affiliations
Kansas City, Kan

From the Head Trauma Unit, Department of Surgery, Section of Neurological Surgery (Drs. Cauthen and Nelson), and the departments of anesthesiology (Drs. Hustead and Saylor) and physiology (Mr. Overman), University of Kansas Medical Center, Kansas City, Kan.

Footnotes
Submitted for publication Nov 19, 1969; accepted Dec 5.

Reprint requests to Section of Neurological Surgery, University of Kansas Medical Center, 39th at Rainbow Blvd, Kansas City, Kan 66103 (Dr. Nelson).

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