This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (96)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

James J. Anthony

Arch Neurol. 1970;22(5):450-454.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

LYMPHADENOPATHY has been recognized as one of the less common side effects of the hydantoin drugs^1-3 for more than a quarter of a century. These drugs have been available for the treatment of epilepsy since 1938. Lymphadenopathy in these patients had been considered a hypersensitivity reaction because of the frequent occurrence of eosinophilia, and benign since it disappeared with discontinuation of the hydantoin. There is a dearth of knowledge about the mechanism of hydantoin lymphadenopathy.

The benignancy of this lymphadenopathy has been questioned.^4-6 Great difficulty has been encountered in the differentiation between "benign" and malignant lymphoid reactions in general.⁴ Hyman and Sommers⁷ reported six cases of lymphoma in association with hydantoin therapy.

A study was undertaken with the hope of clarifying the relationship between hydantoin therapy and malignant lymphoma. A review of the literature was processed, and then a retrospective study of necropsies undertaken to . . . [Full Text PDF of this Article]

Author Affiliations
Cincinnati

From the Department of Neurology, University of Cincinnati College of Medicine and the Cincinnati General Hospital, Cincinnati. Mr. Anthony is a senior medical student at the University of Cincinnati College of Medicine.

Footnotes
Submitted for publication Aug 25, 1969; accepted Oct 20.

Reprint requests to Department of Neurology, Cincinnati General Hospital, Cincinnati 45229 (Mr. Anthony).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?