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Generalized Muscular Stiffness, Fasciculations, and Myokymia of Peripheral Nerve Origin
William E. Wallis, MD;
Alan Van Poznak, MD;
Fred Plum, MD
Arch Neurol. 1970;22(5):430-439.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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THE PERIPHERAL nerve disorders, unlike central nervous system and muscle diseases, have not been widely recognized as causes of generalized muscular stiffness. Isaacs,1,2 in 1961 and 1967, reported three patients with an entity of generalized muscular stiffness, fasciculations, continual electromyographic (EMG) activity at rest and depressed deep tendon reflexes. The muscular stiffness and continual EMG activity were abolished by curare but persisted during spinal anesthesia and after peripheral nerve blocks, suggesting that the syndrome was due to isolated, spontaneous, peripheral nerve hyperactivity. Isaacs also discovered that diphenylhydantoin (DPH) induced a substantial and sustained decrease in the muscular stiffness. Similar cases were reported by Mertens and Zschocke3 and by Levy et al,4 both groups confirming the effects of spinal anesthesia and curare. Mertens and Zschocke3 also found carbamazepine as effective as DPH in treatment. Sig
wald et al,5 Gardner-Medwin and Walton,6 and Hughes and
. . . [Full Text PDF of this Article]
Author Affiliations
New York
From the departments of neurology (Drs. Wallis and Plum) and anesthesiology (Dr. Van Poznak), New York Hospital-Cornell Medical Center, New York.
Footnotes
Submitted for publication Sept 8, 1969; accepted Oct 25.
Reprint requests to Department of Neurology, New York Hospital-Cornell Medical Center, New York 10021 (Dr. Plum).
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