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Thomas H. Milhorat, MD; Ronald G. Clark, PhD; Mary K. Hammock, MD; Philip P. McGrath

Arch Neurol. 1970;22(5):397-407.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IT HAS recently been shown¹ that following effective obstruction of the fourth ventricle and caudal aqueduct, hydrocephalus develops as an acute, rapidly progressive process. The initial rate of progression is precipitous, and within a few hours the hydrocephalic changes are advanced. Thereafter, the rate of ventricular enlargement slows abruptly and continues to decrease until a moderate, stable, and chronically progressive rate is established.

Within hours of complete ventricular obstruction, a number of changes, developing in response to acute ventricular enlargement, are seen in the ependyma and surrounding brain.² The changes are severe and are probably accompanied by a diffuse alteration in the permeability of the ventricular surface.³ It was noted that once these changes are well established, the rate of ventricular enlargement slows perceptibly.

The current paper reports some further observations on the structural and permeability changes of the ventricular surface in acute obstructive hydrocephalus. The . . . [Full Text PDF of this Article]

Author Affiliations
Bethesda, Md

From the Branch of Surgical Neurology, National Institute of Neurological Diseases and Stroke, Bethesda, Md (Drs. Milhorat and Hammock), Department of Neurosurgery, the New York Hospital-Cornell Medical Center, New York (Dr. Milhorat), and Laboratory of Pathology, Division of Biological Standards, National Institutes of Health, Bethesda, Md (Dr. Clark and Mr. McGrath).

Footnotes
Submitted for publication Sept 24, 1969; accepted Oct 13.

Read before the centennial meeting of the Harvey Cushing Society, Cleveland, April 14, 1969.

Reprint requests to Branch of Surgical Neurology, National Institute of Neurological Diseases and Stroke, Bethesda, Md 20014 (Dr. Milhorat).

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