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A Clinical and Electroencephalographic Study

Cesare T. Lombroso, MD; Giuseppe Erba, MD

Arch Neurol. 1970;22(4):321-334.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE MECHANISMS underlying human seizures generalized from the start and those that become so secondarily have not been clearly elucidated. The experimental data accumulated in the last two decades still seem to weigh in favor of a subcortical integrating system as the main agent involved,^1,2 despite the arguments based on electrographic observations^3,4 and on findings of depth electrography and stimulation in man,^5,6 as well as those based on findings in free cortical slabs or on cortical-callosal preparations in animals.^7,8

While waiting for further clarification of the mechanisms, the clinician, whenever confronted by electroencephalograms with bilaterally synchronous discharges of the spike and wave variety, associated or not with focal features, is faced with the task of distinguishing between "primary" and "secondary bilateral synchrony." The latter term was first introduced by Penfield⁹ and Tuckel and Jasper¹⁰ to protect the integrity of the "centrencephalic" hypothesis . . . [Full Text PDF of this Article]

Author Affiliations
Boston

From the Seizure Unit and Division of Neurophysiology, Department of Neurology, Children's Hospital Medical Center, and the Department of Neurology, Harvard Medical School, Boston. Dr. Erba is now at the Department of Neurology, Montreal General Hospital, Montreal.

Footnotes
Submitted for publication Aug 13, 1969; accepted Oct 8.

Read in part before the 94th annual meeting of the American Neurological Association, Beverly Hills, Calif, June 9-11, 1969.

Reprint requests to Children's Hospital Medical Center, 300 Longwood Ave, Boston 02115 (Dr. Lombroso).

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