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Histochemistry and Electron Microscopy

George H. Klinkerfuss, MD; Michael J. Haugh, MD

Arch Neurol. 1970;22(4):309-320.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE application of refined morphologic techniques to human neuromuscular disorders in recent years produced greater diagnostic accuracy in established diseases and recognition of increasing numbers of previously undescribed disorders. Unfortunately, many of these recent observations provide no clear-cut explanation of, or obvious application to, the pathogenesis of neuromuscular disease.

When applied to classical experimental conditions in animals, these same methods allow more meaningful observations of cause and effect. Several investigators^1-3 studied the effect of denervation on histochemical staining of various types of muscle fibers. Pellegrino and Franzini⁴ investigated similar stages of denervation with electron microscopic techniques. Engel et al⁵ reported the histochemical investigation of muscle after tenotomy, while Walker and his coworkers⁶ have published related electron microscopic observations. Karpati and Engel⁷ investigated the effects of cordotomy on muscle by histochemical techniques. Various toxic myopathies have received considerable attention in the ultrastructural literature.

Little attention . . . [Full Text PDF of this Article]

Author Affiliations
St. Louis

From the Department of Neurology, Washington University School of Medicine, St. Louis.

Footnotes
Submitted for publication Oct 8, 1969; accepted Oct 25.

Reprint requests to Department of Neurology, Washington University School of Medicine, 660 S Euclid Ave, St. Louis 63110 (Dr. Klinkerfuss).

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