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A Double-Blind Study of the Effect of Folic Acid Treatment in Patients With Drug-Induced Subnormal Serum Folates

O. Nygaard Jensen, MD; O. Vendelin Olesen, RPh

Arch Neurol. 1970;22(2):181-182.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN a previous study the present authors¹ confirmed the numerous reports of a high frequency of subnormal serum folates (SF) in patients with epilepsy treated with diphenylhydantoin, phenobarbital, and primidone.

The clinical importance of these drug-induced subnormal SF levels is unknown. Reynolds² and Strachan and Henderson³ have put forward the hypothesis, that folate deficiency may lead to neuropsychiatric disorders. Reynolds² observed an improvement in the mental state and a corresponding increase in fit frequency in patients during folic acid administration, whereas Hawkins and Meynell⁴ found folic acid treatment to cause a decrease in fit frequency. Horwitz et al,⁵ in a controlled study, did not observe any effect of folic acid administration in respect to peripheral neuropathy in patients with subnormal SF levels due to anticonvulsant drugs.

The aim of the present study has been to investigate in patients suffering from epiledsy and with drug-induced . . . [Full Text PDF of this Article]

Author Affiliations
Dianalund, Denmark

From the Department of Epileptic Diseases (Dr. Jensen) and the Central Laboratory (Dr. Olesen), the Filadelfia Colony, Dianalund, Denmark.

Footnotes
Submitted for publication Aug 25, 1969; accepted Sept 29.

Reprint requests to the Central Laboratory, Filadelfia Colony, 4293 Dianalund, Denmark (Dr. Olesen).

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