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Ninan T. Mathew, MD, DM (Neurol); Jacob C. Jacob, FRCP(C); Jacob Chandy, MSc, FRCS(C)

Arch Neurol. 1970;22(1):68-74.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

SLOWLY progressive ptosis and ophthalmoplegia, sparing the pupil was called "progressive nuclear ophthalmoplegia" for many years and was attributed to the degeneration of oculomotor nuclei. It is only since the important papers of Sandifer¹ in 1946 and Kiloh and Nevin² in 1951 that the myopathic origin of this disease has been generally recognized. In several cases, the diagnosis of myopathy has been supported by biopsy of levator palpebrae or one of the recti^3-6 and, in a few, by electromyography of ocular muscles.^4,7 The most conclusive evidence that the condition is muscular, and not nuclear is provided by autopsied cases of Beckett and Netsky⁸ and Schwarz and Liu.⁹ They found no significant abnormalities of oculomotor nuclei or nerves while muscles showed changes compatible with dystrophy.

In this subgroup of muscular dystrophy, the dystrophic process begins in the extraocular muscles with initial complaints of ptosis, . . . [Full Text PDF of this Article]

Author Affiliations
Vellore, South India

From the Department of Neurological Sciences, Christian Medical College Hospital, Vellore, South India. Dr. Jacob is now at St. John's General Hospital, Newfoundland, Canada.

Footnotes
Submitted for publication Sept 30, 1968; accepted Sept 3, 1969.

Reprint requests to the Department of Neurological Sciences, Christian Medical College Hospital, Vellore-4, South India (Dr. Mathew).

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