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Absence of Fibrillation After Prolonged and Reversible Conduction Block

Emery D. Robert, MD, ScD; Yvo T. Oester, MD, PhD

Arch Neurol. 1970;22(1):57-63.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

SPONTANEOUS fibrillation potentials occurring in skeletal muscle after surgical denervation are one of the classical signs of denervation sensitization. At present, no satisfactory explanation is available for the occurrence of this pathological change. Several theories in the past have pointed to the possible role of the neurotransmitter and/or nerve impulse activity as being essential for physiological maintenance of muscle. The effect of a prolonged and reversible simple nerve impulse deprivation on the electromyographic potentials of the skeletal muscle has not been reported, prior to a preliminary report by the present authors.¹ In this study, a continuous conduction block of the sciatic nerve of the rabbit was maintained for eight days, with a silicone polymer-lidocaine implant. This resulted in sustained absence of nerve impulses and corresponding limb paralysis. Shortly after removal of this reversible block, essentially normal sensory and motor functions returned. The electrophysiological findings of these muscles form . . . [Full Text PDF of this Article]

Author Affiliations
Hines, Ill

From the Department of Pharmacology, Loyola University Stritch School of Medicine, and the Research Service, Veterans Administration Hospital, Hines, Ill.

Footnotes
Submitted for publication July 11, 1969; accepted July 29.

Reprint requests to Box 98, Hines, Ill 60141 (Dr. Oester).

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