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Inhibition of Antidiuretic Hormone Secretion by Diphenylhydantoin
Marshal P. Fichman, MD;
Charles R. Kleeman, MD;
John E. Bethune, MD
Arch Neurol. 1970;22(1):45-53.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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INCREASED secretion of antidiuretic hormone (ADH) has been implicated in many hyponatremic disorders associated with impaired water excretion. This increased ADH release may be due to nonosmotic stimulation in response to volume depletion, to certain pharmacological agents, or frequently to an "inappropriate" ADH secretion secondary to tumors, pulmonary disease, or central nervous system (CNS) disease.1 The only previously known chemical inhibitor of ADH release other than water is ethanol.2 More recently, Lee et al3 have shown that diphenylhydantoin corrected the impaired water excretion of two patients with the syndrome of inappropriate ADH secretion. To further clarify the mechanism of ADH inhibition by diphenylhydantoin sodium (Dilantin) we have studied the effect of this drug in six patients with the inappropriate ADH syndrome and in eight normal subjects.
Materials and Methods
All clinical studies were performed in the Clinical Research Center of the University of Southern California School
. . . [Full Text PDF of this Article]
Author Affiliations
Los Angeles
From the Department of Medicine, the Los Angeles County-University of Southern California Medical Center (Drs. Fichman and Bethune), and the Cedars-Sinai Medical Center (Dr. Kleeman), Los Angeles.
Footnotes
Submitted for publication May 24, 1969; accepted July 3.
Reprint requests to University of Southern California School of Medicine, 2025 Zonal Ave, Los Angeles 90033 (Dr. Fichman).
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