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Its Relationship to Brain Norepinephrine Concentrations

Donald J. Reis, MD; Dudley T. Moorhead II, MD; Nancie Merlino, MA

Arch Neurol. 1970;22(1):31-39.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

SHAM RAGE behavior in the cat, when produced by electrical stimulation^1,2 of the brain or by acute transection of the brain stem,³ is associated with a fall in the Concentration of brain norepinephrine without change in the content of brain dopamine or serotonin. The fall in the concentration of norepinephrine appears to be the result of augmented activity of norepinephrine containing neurons^4,5 with the release of norepinephrine exceeding the rate of resynthesis. Furthermore, it has been proposed⁶ that the neuronal release of norepinephrine is necessary for the appearance of the behavior, at least when produced by acute brain stem transection.

If neuronal release of norepinephrine serves to trigger sham rage, it would be expected that norepinephrine (levarterenol bitartrate) introduced exogenously to receptor sites in the brain should also result in the excited behavior. However, this does not seem to be the case. When administered parenterally, . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Department of Neurology, Cornell University Medical College, New York.

Footnotes
Submitted for publication Aug 13, 1969; accepted Aug 19.

Reprint requests to the Department of Neurology, Cornell University Medical College, New York 10021 (Dr. Reis).

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