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Intracellular Electromyography

John E. Brooks, MB, MRCP

Arch Neurol. 1970;22(1):27-30.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

DENERVATION of striated muscle leads to characteristic histological, histochemical, physiological, and pharmacological changes which have been ascribed to the loss of a trophic influence of nerve on muscle. The exact nature of this trophic effect has not been determined, although the release of acetylcholine at the motor end-plate seems necessary to maintain the relative insensitivity of normal muscle fibers to this substance away from the end-plate region.^1,2 The observations of Miledi^3,4 suggest that an influence other than acetylcholine is also important. Eccles⁵ has postulated the existence of a trophic substance which passes from nerve to muscle and is independent of neural activity.

Since denervation of muscle leads to a loss of muscle activity, and disuse of muscle without denervation can also lead to change,^6,7 it seems necessary to consider the role of disuse alone in the pathogenesis of the denervation change.

It has been demonstrated . . . [Full Text PDF of this Article]

Author Affiliations
St. Louis

From the Department of Neurology and the Beaumont-May Institute of Neurology, Washington University School of Medicine, St. Louis.

Footnotes
Submitted for publication July 25, 1969; accepted Aug 20.

Reprint requests to Department of Neurology, Washington University School of Medicine, 660 S Euclid Ave, St. Louis 63110 (Dr. Brooks).

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