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Effects of Cold Injury on Six Enzymes in Rat Brain
W. George Bingham, Jr., MD, PhD;
Stephen E. Paul, MD;
K. S. Suryanarayana Sastry, MSc
Arch Neurol. 1969;21(6):649-660.
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IN RECENT years, the lysosome has been established as a major source of the acid hydrolytic enzymes.1-6 Novikoff4 has summarized the existing information pertaining to the function of this organelle within the nervous system. The reader is referred to this excellent review for details. In brief, current theory holds that the lysosome performs an integral role in normal cellular digestion, is involved in ridding the cell of waste products through phagocytic activity, and may participate in autodigestion and removal of the parent cell following cell death. The term "suicide bag," proposed by deDuve2,7 to emphasize the catabolic activities of the lysosome, has engendered an extension of the concept of autolysis to tissue injury. This attractive theory proposes that injuries, which interfere with cellular oxidative metabolism (which would include most types of injury), promote accumulation of metabolic products resulting in regional acidosis favorable to the action of
. . . [Full Text PDF of this Article]
Author Affiliations
Columbus, Ohio
From the Division of Neurological Surgery, Ohio State University Hospital, Columbus, Ohio.
Footnotes
Submitted for publication July 22, 1969; accepted Aug 7.
Reprint requests to the Division of Neurological Surgery, Ohio State University Hospital, 410 W Tenth Ave, Columbus, Ohio 43210 (Dr. Bingham).
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