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Sphingomyelin in Lewy Inclusion Bodies in Parkinson's Disease
Willem A. den Hartog Jager, MD
Arch Neurol. 1969;21(6):615-619.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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THE INCLUSION bodies, which were later to receive his name, were first described by Lewy1 in the substantia innominata and the dorsal vagal nucleus in paralysis agitans.
Trétiakoff2 described these bodies in the substantia nigra.
Greenfield and Bosanquet3 found Lewy bodies in the substantia nigra in 18 of 19 cases of idiopathic paralysis agitans and in the locus ceruleus in the 19th case (substantia nigra not present). In none of the ten cases of postencephalitic parkinsonism and none of the 22 control subjects of the same age but without parkinsonism were Lewy bodies found.
Lipkin4 studied 53 patients with Parkinson's disease and found Lewy bodies in 44% of the postencephalitic cases and 86% of the idiopathic cases.
Bethlem and den Hartog Jager5 corroborated the findings of Greenfield and Bosanquet3 in an investigation of the substantia nigra and locus ceruleus in 15 patients with
. . . [Full Text PDF of this Article]
Author Affiliations
Amsterdam
From the Department of Neurology, Laboratory of Experimental Neurology, Wilhelmina Gasthuis, University of Amsterdam, Amsterdam.
Footnotes
Submitted for publication June 2, 1969; accepted June 17.
Reprint requests to the Department of Neurology, Laboratory of Experimental Neurology, Wilhelmina Gasthuis, University of Amsterdam, Amsterdam.
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