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The Effect on Striatal Amines in the Monkey

Arthur F. Battista, MD; Menek Goldstein, PhD; Susumu Nakatani, MD; Berta Anagnoste, MD

Arch Neurol. 1969;21(6):611-614.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IT HAS BEEN reported by Hornykiewicz¹ that the level of dopamine is very low in the striata of patients with parkinsonism. Cotzias et al² reported that levodopa given orally to patients with parkinsonism decreases rigidity. Since dopa is the precursor of dopamine and passes the blood-brain barrier where it is converted to dopamine by the decarboxylase enzyme, the improvement of rigidity in patients with Parkinson's disease might be associated with an increase in the striatal dopamine. Studies have also shown that administration of levodopa to normal animals increases the cerebral dopamine.³ In the monkey, Poirier and Sourkes⁴ found a marked decrease of dopamine in the striatum ipsilateral to a lesion placed in the ventromedial tegmental area. It has been found also that the uptake and storage of radioactive labelled intraventricular dopamine is almost completely impaired in the striatum ipsilateral to the tegmental lesion.⁵

A . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the departments of neurological surgery, psychiatry, and neurology, New York University Medical Center, New York.

Footnotes
Submitted for publication May 9, 1969; accepted July 14.

Reprint requests to the Department of Neurological Surgery, New York University Medical Center, New York 10016 (Dr. Battista).

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