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A Comparative Study

Hooshang Hooshmand, MD; Janet Dove, MS; Sidney Houff, BS; Cary Suter, MD

Arch Neurol. 1969;21(5):499-509.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

STEROIDS^1-24 (especially prednisolone and dexamethasone) and hypertonic solutions^25,26 (especially urea^27-30 and mannitol^31-35) have been used for the medical treatment of increased intracranial pressure. Each drug has advocates and opponents. Among other controversial subjects, the phenomenon of "rebound overshoot"^36-39 has remained unsolved. There are some³⁸ who emphasize the importance of the presence of the secondary overshoot of pressure after the use of hypertonic solutions, and others³⁷ who deny this phenomenon.

The purpose of this study is to compare the effects of the hypertonic solutions as well as steroids on cerebrospinal fluid (CSF) pressure in normal and pathological states with special reference to pressure changes and the problem of "overshoot." To begin with, it was suspected that the above mentioned drugs may have a different effect on normal vs pathological states of the brain and CSF pressure. For this reason, the study was carried . . . [Full Text PDF of this Article]

Author Affiliations
Richmond, Va

From the Laboratories of Experimental Neurology and Neurochemistry, Division of Neurology, Medical College of Virginia, Richmond, Va.

Footnotes
Submitted for publication June 12, 1969; accepted July 21.

Reprint requests to Division of Neurology, Box 211, Medical College of Virginia, Richmond, Va 23219 (Dr. Hooshmand).

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