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Double-Blind Study

John M. Freeman, MD

Arch Neurol. 1969;21(4):431-434.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

DAWSON'S encephalitis is a progressive degenerative disease of the central nervous system secondary to a chronic viral infection. Histologic, electron microscopic, immunologic, and immunofluorescent studies indicate that the etiologic agent in this disease is the rubeola virus. In addition, the rubeola virus has been cultured from brain tissue obtained at cerebral biopsy from several patients. As a chronic progressive infection of the brain, this disease might be susceptible to antiviral chemotherapy. Preliminary trials suggested that 5-bromo-2'-deoxyuridine (BUDR) might alter the course of the disease.^1,2 To further evaluate this preliminary data, as well as to acquire detailed information regarding the course of Dawson's encephalitis, a double-blind study was undertaken using BUDR and placebo.

Materials and Methods

Patients were included in the study if all the following characteristics of Dawson's encephalitis were manifest²: (1) intellectual or personality change; (2) myoclonic jerks; (3) periodic bursts of slow wave or synchronous . . . [Full Text PDF of this Article]

Author Affiliations
Stanford, Calif

From the Department of Pediatrics and Human Development, Stanford University School of Medicine, Stanford, Calif. Dr. Freeman is now with the Department of Neurology, Johns Hopkins Hospital, Baltimore.

Footnotes
Submitted for publication May 24, 1969; accepted June 24.

Reprint requests to the Department of Neurology, Johns Hopkins Hospital, Baltimore 21205.

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