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Report of a Case and Review of the Literature

Earl R. Olsen, MD

Arch Neurol. 1969;21(4):401-412.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

CLASSIC hemophilia is a congenital coagulation defect caused by an absence or low concentration of the plasma protein factor VIII,^1,2 which results in impairment of the first phase of coagulation.^3-5 (Less common forms are caused by deficiencies in factor IX^6,7 and factor XI.⁸) It is carried on a sex-linked recessive gene which is transmitted to some male offspring by a carrier mother, and it can occasionally be seen in female offspring of a carrier mother and a hemophilic father.

Intracranial hemorrhage is now the leading cause of death in all types of hemophiliacs^9,10: Kerr¹¹ reported a mortality of 33% and Silverstein¹² a mortality of 71%. Approximately 10% of all hemophiliacs have intracranial hemorrhages, of which 45% are in the subdural and epidural spaces.¹² Despite this frequency, only 24 attempts at surgical treatment of intracranial hemorrhage in factor-VIII-deficient hemophiliacs have been reported . . . [Full Text PDF of this Article]

Author Affiliations
San Francisco

From the Division of Neurological Surgery, University of California Medical Center, San Francisco.

Footnotes
Submitted for publication April 18, 1969; accepted May 21.

Read before the San Francisco Neurological Society, Pebble Beach, Calif, May 12, 1968.

Reprint requests to Division of Neurological Surgery, University of California Medical Center, San Francisco 94122 (Dr. Olsen).

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