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I. Potential Role of Phenolic Acids in the Neurological Manifestations of Uremia

N. Burgess Record, MD; James W. Prichard, MD; Brian B. Gallagher, MD, PhD; David Seligson, MD

Arch Neurol. 1969;21(4):387-394.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

MANY ORGANIC acids accumulate in renal failure.¹ The role of phenolic acids in the pathogenesis of uremia has been reviewed by Schreiner and Maher² and others.^3-10 Blood phenols are primarily derived from the action of intestinal bacteria on protein derivatives containing aromatic amino acids. They are absorbed from the gut, conjugated in the liver, and excreted principally by the kidneys. Normally total plasma phenols including various amino acids, phenols, and aromatic hydroxy acids do not exceed 0.1 mg/100 ml. Marked elevations of free and conjugated phenols have been detected in uremia and reported to correlate with uremic symptoms, especially those of central nervous system (CNS) depression.^3-6

The present study was undertaken to evaluate in vivo the potential contribution of the phenolic compound, 3,4-dihydroxybenzoic acid (3,4-DHBA) (protocatechuic acid) to the pathogenesis of uremia. This compound was selected because it is excreted in considerable amounts (46 . . . [Full Text PDF of this Article]

Author Affiliations
New Haven, Conn

From the sections of neurology and clinical pathology, Yale University School of Medicine, New Haven, Conn.

Footnotes
Submitted for publication April 16, 1969; accepted May 24.

Reprint requests to the Section of Neurology, Yale University School of Medicine, 333 Cedar St, New Haven, Conn 06510 (Dr. Gallagher).

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