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Relations to 17-Hydroxycorticosteroid Levels

George R. Heninger, MD; Roger K. McDonald, MD; William R. Goff, PhD; Arne Sollberger, MD

Arch Neurol. 1969;21(3):330-337.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ALTHOUGH there are many direct effects of 17-hydroxycorticosteroids (170HS) on the central nervous system (CNS),¹ a diurnal change in CNS activity produced by a diurnal change in blood 170HS levels has not been demonstrated. In animals, 170HS increase brain excitability,^1,2 lower seizure thresholds,^1,2 increase behavioral and electrical arousal,^2-4 increase amplitudes and decrease latencies of evoked responses in several multisynaptic pathways,^2,5 and alter free-operant avoidance behavior.⁶ Single unit studies are more complex as they demonstrate both excitation and inhibition following cortisol (hydrocortisone).^7,8 In humans, 17OHS often alter the electroencephalogram and increase seizure frequency.^9,10 In adrenal insufficiency, 17OHS normalize the EEG,¹¹ the low olfactory,¹² gustatory,¹³ and auditory detection thresholds,¹⁴ and shorten the latency of the visual evoked response.¹⁵ A significant positive correlation has been reported between urinary 170HS levels and seizures in one case¹⁶ and . . . [Full Text PDF of this Article]

Author Affiliations
New Haven, Conn

From the Connecticut Mental Health Center (Drs. Heninger; McDonald; and Sollberger), West Haven Veterans Administration Hospital (Dr. Goff), and the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn.

Footnotes
Submitted for publication April 24, 1969; accepted May 12.

Read in part before the 22nd annual meeting of the American Electroencephalographic Society, Sept 12, 1968.

Reprint requests to the Connecticut Mental Health Center, 34 Park St, New Haven, Conn 06508 (Dr. Heninger).

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