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Associated With Low Molecular Weight M in the Serum and Cerebrospinal Fluid

Robert C. Griggs, MD; Warren Strober, MD; Dale E. McFarlin, MD

Arch Neurol. 1969;21(3):303-314.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IMMUNOGLOBULIN M, M, is not detectable by immunoprecipitation techniques in normal cerebrospinal fluid (CSF).¹ In early studies, this immunoglobulin was shown to be a macroglobulin with a sedimentation coefficient of 19S.^2,3 In recent studies,^3-13 however, smaller proteins with antigenic determinants identical with the heavy chain (µ) of 19S-M (HMW-M) have been demonstrated. These lower molecular weight forms of M (LMW-M) occur in patients with a variety of disorders including systemic lupus erythematosus (SLE),^6,7 ataxia-telangiectasia,⁷ antibody deficincy syndromes,^5,7,12,13, malignancy of the plasma-cell-lymphatic system,¹⁰ and as an M protein in a lymphomatous disorder.⁹ Some LMW-M proteins have been shown to have antinuclear and incomplete isohemagglutinin activity.⁷ To date, LMW-M has not been demonstrated in the CSF.

This report presents a case characterized clinically by recurrent central nervous system (CNS) symptoms and skin findings typical of SLE, in whom LMW-M was found in . . . [Full Text PDF of this Article]

Author Affiliations
Bethesda, Md

From the Medical Neurology Branch, National Institutes of Neurological Diseases and Stroke (Drs. Griggs and McFarlin), and the Metabolism Branch, National Cancer Institute (Dr. Strober), National Institutes of Health, Bethesda, Md.

Footnotes
Submitted for publication April 21, 1969; accepted May 7.

Read in part before the eastern section of the American Federation for Clinical Research, Boston, Dec 6, 1968.

Reprint requests to the Medical Neurology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, Md 20014 (Dr. Griggs).

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