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O. Nygaard Jensen, MD; O. Vendelin Olesen, RPh

Arch Neurol. 1969;21(2):208-214.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN RECENT years there has been an increasing interest in the possible interplay between folic acid and anticonvulsive drugs. Subnormal serum folate levels have been found in a large number of patients treated with anticonvulsive drugs (Klipstein,¹ Reynolds et al,² Reynolds,³ and Ibbotson et al⁴). However, Weckman and Lehtovaara⁵ did not find any significant difference between the serum folate levels of a group of treated epileptics and a group of nontreated normal control subjects.

Furthermore, about 50 cases are reported in which antiepileptic drugs are stated as the causative agents of a folic acid deficiency resulting in megaloblastic anemia (review by Stokes and Fortune⁶).

In various reports, Reynolds⁷ has put forward the hypothesis that the presumed forlicacid deficiency may cause dementia and schizophrenia-like psychoses in patients with epilepsy. Also, Strachan and

Henderson⁸ maintain that folic acid deficiency may give rise to . . . [Full Text PDF of this Article]

Author Affiliations
Dianalund, Denmark

From the Department of Epileptic Diseases (Dr. Jensen), and the Central Laboratory (Dr. Olesen), the Filadelfia Colony, Dianalund, Denmark.

Footnotes
Submitted for publication Dec 9, 1968; accepted Jan 8, 1969.

Reprint requests to Central Laboratory, Filadelfia Colony, Dianalund, Denmark (Dr. Olesen).

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