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John Prineas, MB, MRCP

Arch Neurol. 1969;21(2):150-156.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE occurrence of widespread epidemics of paralysis caused by adulteration of food with triorthocresyl phosphate (TOCP) has encouraged numerous reports of the clinical effects and histological changes induced in the peripheral and central nervous system (CNS) in man by this chemical. Cavanagh and his associates^1-3 have shown in experimental animals that the distal parts of the longest nerve fibers in the spinal cord and in the peripheral nerves show the earliest and most extensive degenerative changes. The manner in which TOCP exerts its neurotoxic effect is not known. Although initially regarded as a specific myelin poison, it is now believed that TOCP acts primarily on the neuron and that myelin disintegration is secondary to axonal destruction.^3-6 It has also been shown that TOCP inhibits pseudocholinesterase activity and other esterases. What role, if any, this plays in the development of the neuropathy is not understood.⁷

The following report . . . [Full Text PDF of this Article]

Author Affiliations
Bronx, NY

From the Saul R. Korey Department of Neurology and the Department of Pathology (Neuropathology), Albert Einstein College of Medicine, Bronx, NY.

Footnotes
Submitted for publication March 6, 1969; accepted April 2.

Read in part before the meeting of the American Association of Neuropathologists, June 1968.

Reprint requests to Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461

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