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Pathogenesis of Onion-Bulb Formations Produced by Repeated Tourniquet Applications

Peter James Dyck, MD

Arch Neurol. 1969;21(1):73-95.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN A PAPER on "Progressive Hypertrophic Interstitial Neuropathy of Infancy," Dejerine and Sottas¹ described the clinical and pathologic features of a recessively inherited, severe, mixed peripheral neuropathy with enlargement of nerves. Subsequently, the enlargement of nerves seenclinically and postmortem and the histologic features of onion-bulb formations were found to be associated with disorders which seemed to be different, as judged by their natural history, pattern of inheritance, and biochemical alterations.^2-8

In reports based on light-microscopic examination of peripheral nerves, there has been some disagreement on the origin and cellular composition of the onion-bulb formation (also called "cuff" or "whorl"). The majority of authors favored a Schwann-cell origin,^6,9-19 though a few of them noted a connective-tissue constituent in the whorl.^14,15 Dejerine and Sottas,¹ and particularly Dejerine²⁰ with AndréThomas,² and others^22-26 favored a connective-tissue origin. That myelinated fibers lay at the center of . . . [Full Text PDF of this Article]

Author Affiliations
Rochester, Minn

From the Section of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minn.

Footnotes
Submitted for publication Nov 18, 1968; accepted Feb 5, 1969.

Reprint requests to the Section of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minn 55901.

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