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Ernst Niedermeyer, MD; Edward R. Laws, Jr., MD; A. Earl Walker, MD

Arch Neurol. 1969;21(1):51-58.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE origin and neurophysiological mechanisms of generalized-synchronous spikewave discharges continue to be subjects of controversy. It was presumed for many years that these discharges arise from the intralaminar thalamic nuclei and thence fan out into the diffuse thalamo-cortical projections.¹ Thus the concept of "centrencephalic" seizures arose to explain petit mal and "pure" grand mal.

The postulated thalamic origin of generalized-synchronous seizure patterns has been challenged by experimental as well as clinical investigations. Depth electroencephalographic studies in epileptic patients with generalized spike-wave complexes often reveal focal components. Bickford² and Bancaud et al³ have implicated the frontal lobe as the origin of generalized spike-wave patterns. Angeleri et al⁴ reported focal limbic spike-activity in presumably centrencephalic epileptics. Independent deep temporal spiking was also noted by Rossi et al⁵ in patients with generalized-synchronous seizure patterns. Walker and Marshall⁶ felt that widespread cortical as well as deep foci could . . . [Full Text PDF of this Article]

Author Affiliations
Baltimore

From the division of Neurological Surgery, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Baltimore.

Footnotes
Submitted for publication Feb 28, 1969; accepted March 27.

Read before the annual meeting of the American Electroencephalographic Society, San Francisco, Sept 13, 1968.

Reprint requests to Johns Hopkins Hospital, 601 N Broadway, Baltimore 21205 (Dr. Niedermeyer).

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